Organ Size Control: Lessons from Drosophila
نویسندگان
چکیده
منابع مشابه
The genetic control of organ growth: insights from Drosophila.
The genetic control of growth ensures that animals grow to reproducible sizes and that tumourous growth is rare. This year, the regulation of organ growth has been studied extensively in Drosophila imaginal discs, and a signalling pathway that regulates organ growth and size has been identified. Furthermore, the role of Drosophila homologues to human tumour suppressor genes and oncogenes in ima...
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The size of plant organs, such as leaves and flowers, is determined by an interaction of genotype and environmental influences. Organ growth occurs through the two successive processes of cell proliferation followed by cell expansion. A number of genes influencing either or both of these processes and thus contributing to the control of final organ size have been identified in the last decade. ...
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changing the length of the cell cycle does not directly The control of growth is fundamental to the developing affect overall organ growth, which indicates that cellular metazoan. Here, we show that CHICO, a Drosophila growth regulation can occur independently of cell cycle homolog of vertebrate IRS1–4, plays an essential role control. in the control of cell size and growth. Animals mutant In h...
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UNLABELLED Control of cessation of growth in developing organs has recently been proposed to be influenced by mechanical forces acting on the tissue due to its growth. In particular, it was proposed that stretching of the tissue leads to an increase in cell proliferation. Using the model system of the Drosophila wing imaginal disc, we directly stretch the tissue finding a significant increase i...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2015
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2015.07.012